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Capsaicin 8% Patch Compared with Pregabalin in the Treatment of Nondiabetic Peripheral Neuropathic Pain: Elevate Trial

Antonio Alcántara Montero*

Conventional treatments for peripheral neuropathic pain may be restricted by factors such as systemic side effects, interactions with other drugs, the slow onset of action, the need for dose adjustments and multiple daily doses. Recently it has been published in the European Journal of Pain a simultaneous non-inferiority study comparing patch capsaicin 8% with pregabalin (flexible dose optimized) in adult patients with nondiabetic peripheral neuropathic pain. According to this study, topical treatment with capsaicin patch 8% was not inferior to pregabalin. This means that the patch capsaicin 8% could be another treatment option for patients with Nondiabetic peripheral neuropathic pain, especially those who are very sensitive to the side effects of systemic medications or for those not wishing oral drug treatment daily.