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What is the Agreement Between 6MWD And CPET Performance in COPD?

Ines Ladeira, Pedro Oliveira, Cristiana Martins, Ricardo Lima MD, Miguel Guimaraes

Introduction: Chronic Obstructive Pulmonary Disease patients typically present breathlessness and reduced exercise capacity. Our study aimed to better understand the correlation between 6MWD and CPET performance.

Methods: We conducted an observational prospective study. Consecutive stable COPD patients referred to the Lung Function Laboratory were recruited.

Results: Our 116 patients were predominantly male (88%), very symptomatic (68% GOLD B or D) and nonexacerbators (69%). Most patients had severe or very severe airflow limitation (55%) - median FEV1 was 48% (IQ 38-68). Median DLCO was 58% (IQ 46-75). Median 6MWD was 480m (406-515) and median workload (CPET) was 64W (46-88) with peakVO2 15.7L/min/kg (13.6-18.1). Median ΔSpO2 was 5% (3-9%) in 6MWT and 2% (1-6) in CPET. FEV1 and DLCO were important predictors of exercise capacity and desaturation in CPET and 6MWT. The 6MWD correlated with CPET peak workload and peak VO2; 6MWD of 440m estimates reduced exercise capacity in CPET (VO2 <60%).

Conclusion: 6MWD can estimate CPET peakVO2.