ஜர்னல் ஆஃப் பார்மகோகினெடிக்ஸ் & எக்ஸ்பெரிமென்டல் தெரபியூட்டிக்ஸ்

சுருக்கம்

Understanding the Pharmacodynamics and Pharmacokinetics of MSCs to Surmount Clinical Restatement Limitations

Michela Salvadori

Lately, mesenchymal stromal stem cells (MSCs) have been proposed as remedial agents because of their promising preclinical features and good safety profile. Still, their preface into clinical practice has been associated with a sour remedial profile. Beginning with substantiation of MSC bio distribution and pressing PK and PD factors, a new PK- PD model is also proposed. According to this proposition, MSCs and their released factors are crucial players in PK, and the efficacity biomarkers are considered applicable for PD in further prophetic preclinical examinations. Account for the PK- PD relationship in MSC translational exploration and proposing new models combined with better biodistribution studies could allow consummation of the pledge of further robust MSC clinical restatement.