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Transcription Factor 7-like 2 (TCF7L2) rs7903146 Polymorphism, Association with Type 2 Diabetes Mellitus Susceptibility

Naglaa Fathy Barseem, Mona F. El- Samalehy and Zeinab A. Kasemy

Objectives: The aim of this study was to investigate the possible role of TCF7L2 rs 7903146 (C/T) variant on susceptibility of T2DM among Egyptian children and adolescents. Patients and methods: 30 T2DM pediatric patients, 20 obese children and 20 control subjects were enrolled in the study and subjected to: anthropometric measurements, routine laboratory studies including lipid profile, fasting serum insulin level and homeostatic model assessment of insulin secretion and β cell function. The rs7903146 (C/T) polymorphism was genotyped using the PCR-RFLP method. Results: T allele of TCF7L2 rs7 903146 (C/T) was associated with T2DM in the study (P<0.001; OR=5.96, 95% CI: (2.58-16.22). Haplotype analyses showed a higher distribution of haplotype TT in the T2DM patients than the control group [56.7% vs. 15.0%, P<0.002; χ2=11.66]. Association of TCF7L2 rs7903146 and clinical and metabolic measures in T2D patients revealed significantly lower levels of fasting insulin and Homa β among carriers of T allele. Also, no significant interaction was found between T2D risk and BMI (SDS) regarding rs7903146 SNP. Conclusion: Our data prove that rs7903146 (C/T) variant of the TCF7L2 gene is associated with T2DM in our study.