மூலக்கூறு மருந்துகள் & ஆர்கானிக் செயல்முறை ஆராய்ச்சி இதழ்

சுருக்கம்

Role of In-silico modeling in Drug Development for Inhalation Treatment

Shengqian Wu, Sharareh Salar-Behzadi and Eleonore Frohlich

In-silico modeling is increasingly being used for simulation of adsorption, distribution, metabolization, and excretion to predict the curve of plasma levels and bioavailabilityof oral drug formulations. Computational models for the prediction of other application routes are less common. Preliminary data shows that GastroPlus^TM simulation software appears suitable for prediction of drug plasma levels of inhaled drugs in healthy individuals. Since also the influence of physiological variations on lung deposition can be simulated, this software could be a valuable tool in the screening of promising formulations.