பார்மசி & லைஃப் சயின்ஸில் ஆராய்ச்சி மற்றும் மேம்பாட்டுக்கான சர்வதேச இதழ்

சுருக்கம்

PLANT DERIVED ANTICANCER AGENTS: A REVIEW

Preeti Singh Sisodiya

Cancer is a major public health burden in both developed and developing countries. Plant-derived compounds have been an important source of several clinically useful anti-cancer agents including taxol, vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, and etoposide derived from epipodophyllotoxin are in clinical use all over the world. About 30 plant derived compounds have been isolated so far and are currently under clinical trials. Cancer chemopreventive agents, many of which are natural products, are capable of preventing or inhibiting the process of carcinogenesis. As with other pharmaceutical agents useful for disease prevention, a pharmacoeconomic analysis of a cancer chemopreventive formulation would need to be considered, and the composition of the formulation should improve over time. A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol, roscovitine, combretastatin A-4 phosphate , betulinic acid and silvestrol are in clinical or preclinical development .