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ORF3a mutations: an adaptive advantage for SARS-CoV-2 pathogenecity

Sougata Niyogi , Parinita Majumdar

The outbreak of severe acute respiratory syndrome in November 2019 resulted in a global public health emergency which warrants investigation of the virulence and pathogenecity of SARS-CoV-2. The reasonably higher mutation rate in SARS-CoV-2 led to the emergence of its numerous genetic variants which is likely to be responsible for COVID-19 associated morbidity and mortality. Mutations in ORF3a protein could modulate viral pathogenecity by interfering with host immune response and apoptotic pathways.