மூலக்கூறு மருந்துகள் & ஆர்கானிக் செயல்முறை ஆராய்ச்சி இதழ்

சுருக்கம்

In-vitro refolding of recombinant human (rh) Prolidase using smart polymer

Sayantap Datta

Statement of the Problem: A member of the metallopeptidase family, Prolidase is an exopeptidase involved in the final steps of the catabolism of proline-rich and hydroxyproline-rich dietary and endogenous proteins such as collagen. Mutations in the gene encoding for prolidase brings about autosomal recessive prolidase deficiency characterized by intractable ulcerations in the skin, varied extent of mental retardation and recurrent infections of the respiratory tract. Prolidase has additionally been known to function similar to organophosphorus acid anhydrolase in hydrolyzing organophosphorus compounds