ஓட்டோலரிஞ்ஜாலஜி: திறந்த அணுகல்

சுருக்கம்

Comparison between the Sinus and Gut Microbiome in Patients with Chronic Sinus Disease

Sanjeev M Balamohan, Alan D Tate, Brittany C Dobson and Jeb M Justice

Objectives: Associations between the gut microbiome and various non-GI related diseases have been detailed in recent studies. This investigation aims to directly compare the gut and sinus microbes in patients with chronic sinus disease and in control patients to determine if any link exists between the sinus and gut microbiota.
Methods: This was a prospective study conducted from February 2016 to August 2017. It was conducted at a tertiary care academic rhinology practice on 16 patients undergoing rhinologic surgery. The primary outcome measure was to determine if any overlap exists between the gut and sinus microbiome in a given subject. A secondary outcome was to assess the effect of prior antibiotic therapy on the diversity of the gut microbiome.
Results: There were 7 patients with chronic rhinosinusitis (CRS) with polyps, 6 patients with CRS without polyps and 3 control patients. Only one patient demonstrated an overlap of sinus and gut microbiotia. In patients receiving a reduced number of antibiotic courses over the past 24 months (0 or 1 course), there was a mean of 7.7 (SD 2.2) gut bacteria isolated from stool samples. In patients receiving more antibiotic courses (2+ courses), there was a mean of 5.1 (SD 2.3) gut bacteria isolated. This difference reached statistical significance (p=0.043).
Conclusion: Minimal overlap between the sinus and gut microbiome was demonstrated, but further studies are needed to elucidate this potential association. This study supports the theory that antibiotics tend to reduce microbial diversity in the gastrointestinal tract.