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Cold Agglutination is a Concern in the Collection and Processing of Hematopoietic Progenitor Cell Products

Thomas James

Similarly, cry globulins can precipitate from plasma when temperatures fall below the central body temperature, resulting in erythrocyte agglutination. Unfortunately, such temperature ranges are commonly encountered outside of the body's circulation, such as in an extracorporeal circuit during hematopoietic progenitor cell collection or human cell therapy laboratory processing. Ex vivo agglutination may cause issues with the collection of product, resulting in adverse effects or product loss. In this section, we hope to share our experience in preventing and responding to recognized incidents of HPC agglutination in our human cell therapy facility.