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CD4⁺T Cells Expansion in P. berghei (NK-65) Infected and Immunized BALB/C Mice

Vineet Kumar, Aruna Rakha, Ruchika Saroa and Upma Bagai

The immune system of malaria infected host undergoes both activation and suppression during different phases of parasite’s life cycle. In Plasmodium chabaudi chabaudi (AS), T helper cells of host have been reported to be necessary for inducing a protective immune response against the blood stages of parasite [1]. T cells provide protection to infection by cytokine-mediated mechanisms or through production of antibodies. Experiments with B cell deficient mice have demonstrated that B cells and antibodies are essential for complete clearance of parasites from blood of the host [2]. Depending upon the cytokines secreted by the Helper T cells, they are classified into two subpopulations: Th1 and Th2 cells. Th1 cells primarily release IFN-γ, IL-2, whereas, Th2 cells secrete IL-4, IL-5, IL-6, IL-10 and IL-13.