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Alveolar-Repairing Effect of 1α,25-Dihydroxyvitamin D3 on Chronic Obstructive Pulmonary Disease Mouse Model Based on Differentiation Inducing: Mini Review

Tomomi Akita, Chikamasa Yamashita

Chronic Obstructive Pulmonary Disease (COPD) is the leading cause of death worldwide, but there is no drug to cure completely. We previously reported for the first time in the world the 1α,25-dihydroxyvitamin D3 can improve emphysema in animal COPD model. The aim of this mini review was to describe the effect of 1α,25-dihydroxyvitamin D3 on alveolar regeneration based on differentiation inducing, which we have found. Indicating the usefulness for 1α,25- dihydroxyvitamin D3 in a COPD mouse model that better reflects human medical conditions, 1α,25-dihydroxyvitamin D3 can be expected for drug candidate for novel therapy of COPD.